Endocrine Abstracts

Parathyroid carcinoma (PC) rarely presents with metastasis at diagnosis and usually in patients also having gross local invasion.Case presentation: We report the case of a 51-year-old postmenopausal woman presenting at our institution in June 2019 with symptomatic hypercalcemia (fatigue, polyuria, constipation and bone pain), but with a surprisingly good general condition. She had been treated with bisphosphonates for osteoporosis (DXA: LS T score &#8722...

Background: Hyponatremia in not uncommon in elderly. Common causes include medication, heart, kidney and liver diseases, digestive loses, syndrome of inappropriate anti-diuretic hormone. Hormonal imbalances are sometimes overlooked. Sudden onset after a recently invasive procedure could challenge the diagnostic.Methods: We present a case report of a severe hyponatremia diagnosed after a coronary angiogram. It is a rare case of hypopituitarism secondary t...

Hypothyroidism is a well-known cause of delayed puberty in children. But in rare instances, hypothyroidism can also be related to isolated menarche. The mechanism remains debatable whilst the overall incidence of the condition remains unknown.Case Report: 6-year girl presented to children’s emergency with 2 days history of vaginal bleeding. Mum reported her being intolerant to cold, constipated and faltering growth compared to her twin sister. Her s...

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease which is characterized by hypocalcaemia and undetectable or inappropriately low serum parathyroid hormone (PTH). Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid removal/injury during neck surgery. From a neuropsychological standpoint, patients with PS-HypoPT present cognitive and neuropsychological symptoms: the more plausible pathophysiological mechanism resides i...

Background: The importance of carcinoembryonic antigen (CEA) assessment in the evaluation of medullary thyroid carcinoma is well known. The role of CEA in the assessment of other neuroendocrine tumors (NET) is not clear. We aimed to evaluate a possible correlation between CEA measurements and the aggressivity of NETs.Methods: We evaluated 56 (36 women) NETs followed in a tertiary center (23 gastrointestinal, 12 pancreatic, 10 pulmonary, 7 without primary...

The ingestion of marine foods is a potential route of contamination by tributyltin (TBT), a biocide organotin used as an antifouling in boat paints. TBT causes a phenomenon known as imposex, that induces, for instance, the irreversible appearance of male sexual characteristics in gastropod females. In mammals, TBT also directly impairs the sexual development. In fact, it is known that TBT can affect women in reproductive age. Our aim was to study whether the maternal exposure ...

Obesity is a multifactorial disease in which environmental conditions and genetic factors play an important pathogenic role [1]. Interestingly, some of these obesogenic environmental and genetic conditions are shared with neurodegenerative diseases (NDD). The common biological mechanisms involved in obesity and NDD are insulin resistance, pro-inflammatory cytokines, and oxidative damage, in turn leading to cognitive dysfunction or cell death. In this aspect, a poly-pharmacolog...

Background: Resistance to thyroid hormone beta (RTHβ) is an inherited syndrome of reduced tissue responsiveness to thyroid hormones (THs). It is driven in 85% of cases by mutations in the thyroid hormone receptor beta (THRb). The estimated incidence is 1:40.000 to 1:19.000 live births. We report the clinical, laboratory, and genetic analysis of a patient with this disorder.Case report: A 12-year-old boy with a history of Attention-Deficit/H...

Introduction: Endogenous Cushing syndrome (CS), is associated with significant morbidity (metabolic, cardiovascular, bone, psychiatric complications among others). Most complications tend to improve if hypercortisolism is controlled but some are only partially reversible or even experience temporary exacerbation.Patients and Methods: We report 2 cases of adrenal Cushing Syndrome (CS). The first is a 72 years-old female with CS caused by bilateral macrono...

Post-surgical hypoparathyroidism occurs as inadvertent removal or irreversible damageparathyroid disease, irreversible or permanent causing decreased action of parathormone leading to hypocalcemia and hypophosphatemia.Clinical Case: A 52-year-old woman referred from our outpatient clinics due to severe hypocalcemia symptomatic; hand and foot cramps, and hyperphosphatemia: albumincorrected calcium. (5.52 mg/dl and phosphate of 6.6 mg/dl). She presents a h...